Mucoepidermoid carcinoma has a major impact on society all over the world. Immunohistochemical and fluorescent microscopic study of histogenesis of salivary mucoepidermoid carcinoma. The second most common minor salivary gland tumour 1240% globally is mucoepidermoid carcinoma. Mucoepidermoid carcinoma of the hard palate in a young. Minor salivary glands are scattered in different areas of the oral cavity such as palate, retromolar area, floor of the mouth, buccal mucosa, lips and tongue, but so far, only a few lingual mec cases have been documented in the literature and most of the studies have shown a. Mucoepidermoid carcinoma soft palate rads iowa head and. We report a case of mucoepidermoid carcinoma mec in the palate of a 43yearold female that exhibited a prominent oncocytic. Mitochondriarich, eosinophilic oncocytes are cells commonly encountered in salivary gland neoplasms. Nov 29, 2014 45yearold male patient with lesion over on the right side of the palate diagnosed as mucoepidermoid carcinoma intermediate stage. Casereport oncocytes in mucoepidermoid carcinoma of the palate. Salivary gland neoplasm, palatal ulcer, wide surgical excision.
Mucoepidermoid carcinoma mec of the salivary gland is believed to arise from pluripotent reserve cells of the excretory ducts that are capable of differentiating into squamous, columnar, and mucous cells. Mar 26, 2018 mucoepidermoid carcinoma soft palate malignant epithelial salivary gland neoplasm 10% of all salivary tumors, 30% of all salivary malignancies about 30% of these tumors arise from the minor salivary glands in the buccal mucosa and soft palate, the rest from major salivary glands arises from ductal epithelium, has both epidermoid and mucinous components appearance. Mucoepidermoid carcinoma of the palate in adolescence. Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. It was first reported by massao and berger in 1942 and first described as a separate pathological entity by stewart et al.
Mucoepidermoid carcinoma of the palate in a 5yearold girl. Diagnostic challenges rammohankumar,1srikantnatarajan,2 k. Mucoepidermoid carcinoma in adults mostly develops between the third and fourth decades, with an equal sex distribution. Mucoepidermoid carcinoma mec is an epithelial salivary gland neoplasm.
The epidemiology is not well documented and varies based upon geography and populations studied. Mucoepidermoid carcinoma of the posteriorlateral border of. Mucoepidermoid carcinoma mec is the most common malignant tumour of the major and minor salivary glands. Mec of the hard palate presents as a slowgrowing, persistent, painless swelling which is soft in consistency. It can mimic most other tumors of the glands, and therefore is often considered in the differential. Mucoepidermoid carcinoma is a tumor that usually occurs in the salivary glands. Mucoepidermoid carcinoma mec of the palate is a common malignancy of minor salivary glands. However it can present in the minor salivary glands, especially in the soft palate. However, reports of high grade transformation in mec are extremely rare, and only two cases have so far been described. Salivary gland cancer is diagnosed in 23 individuals per 100,000 people each year, and 3035% of these are mucoepidermoid carcinomas. It accounts for about 3% of all head and neck tumors 10, 43.
We report the case of a 72yearold malay female after presentation with sore throat, fever and odynophagia, was diagnosed with mucoepidermoid carcinoma of the soft palate. Since then, they have become well recognized as a common salivary gland neoplasm, accounting for approximately 35% of all. Mucoepidermoid carcinoma of maxillary sinus pathology. Epidemiology mucoepidermoid carcinomas are seen throughout all. Pdf mucoepidermoid carcinoma of the palate in a child. It has been estimated that about 1% to 5% of all salivary gland tumors develop in children and adolescents 1, 8, and mec is the most common malignancy 5, 9, 39, 40. It accounts for 59% of all salivary gland neoplasms. Mucoepidermoid carcinoma of hard palate request pdf. We presented a 46yearold woman with an enlarging hard palate mass that appeared as a chondrosarcoma on ct but that was diagnosed, by pathology, as an intermediategrade mucoepidermoid carcinoma with extensive ossifications. Mucoepidermoid carcinoma is more frequent in females, occurs in the fifth decade of life and is usually found in the parotid gland.
Had a surgery 20 days ago to remove a lump on my right palate 1. Mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth. Similar morphology to mucoepidermoid carcinoma arising in the head and neck with a mixture of mucous cells, squamous cells and intermediate cells. Aug 02, 2011 mucoepidermoid carcinoma, or cancer of the salivary gland, is a genetic disease in the sense that it occurs due to changes mutations in genes that regulate how cells in the body divide. Jun 18, 20 mucoepidermoid carcinoma is a type of cancer of the salivary glands. Mar 12, 2012 ive been diagnosed with mucoepidermoid carcinoma involving the minor salivary glands on the palate.
Minor salivary gland mucoepidermoid carcinoma in children and. Just diagnosed with mucoepidermoid on the upper left palate. Initially, he complained about a progressive swelling in the last 60 days. The clinicopathologic features and results of log rank tests for clinical variables are shown in tables 1 and 2respectively. Is it necessary to resect bone for lowgrade mucoepidermoid. Mucoepidermoid tumour, salivary gland neoplasms, minor salivary gland introduction.
Although the palate is reported to be the most common site, and recent reports have confirmed that mucoepidermoid carcinoma is the most common malignant neoplasm, we know of few large series of cases that outline the management of these cases. Aug 12, 2014 minor salivary gland tumors in children are uncommon. It accounts for soft palate malignant epithelial salivary gland neoplasm 10% of all salivary tumors, 30% of all salivary malignancies about 30% of these tumors arise from the minor salivary glands in the buccal mucosa and soft palate, the rest from major salivary glands arises from ductal epithelium, has both epidermoid and mucinous components. Mucoepidermoid carcinoma mec represents the most common malignant tumor of the salivary glands. Oncocytes in mucoepidermoid carcinoma of the palate. Mucoepidermoid carcinomas represent a distinct type of tumor. Mucoepidermoid carcinoma mec is the most common malignant salivary gland tumor. Approximately half of the tumors occur in the major salivary glands. The number of individuals diagnosed with cancer is increasing. Mucoepidermoid carcinoma genetic and rare diseases. Mucoepidermoid carcinoma is often associated with tobacco smoking. Mucoepidermoid carcinoma mec accounts for % of all malignancies occurring in maxillary sinus. However, mucoepidermoid carcinoma is not inherited from a parent or passed down through a family. Mucoepidermoid carcinoma 150014 mucoepidermoid carcinoma 203632.
Mucoepidermoid carcinoma involving the palate with lamellated. Jul 01, 2016 mucoepidermoid carcinomas are the most common type of salivary gland malignancies. Ossifications in mucoepidermoid carcinomas are rare. The overall 5year survival rates vary from 92 to 100% in lowgrade tumors, 62 to 92% in intermediategrade tumors, and 0 to 43% in highgrade tumors pires et al. Through computed tomography scan, it was noted intraosseous involvement in the maxilla involving dental apex. Mucoepidermoid carcinoma is the histologic subtype of salivary gland tumors for which grading is the most prognostically and therapeutically relevant factor seethala, 2011. Intraoral mucoepidermoid carcinoma of salivary glands. Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands.
The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. High grade transformation in mucoepidermoid carcinoma of the. It is critical to differentiate such tumors from common benign salivary gland lesions. Pdf salivary gland tumors are rare in children but when they involve the minor salivary glands, there is an increased risk that they will be. Triantafillidou k, dimitrakopaulos j, iordanidis f, koufoginnis d. The two most common tumors were pleomorphic adenoma 181 cases, 33. Prognostic factors of palatal mucoepidermoid carcinoma. The majority of cases occurring in the 4th and 5th decades of life and they are histologically lowgrade malignant neoplasm usually affecting the mandible.
Mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands among children and adults and shows a wide, nearly uniform age distribution, with diminution in pediatric and geriatric life. Sep 18, 2019 mucoepidermoid carcinoma mec is the most common malignant tumor of the salivary gland. Mucoepidermoid carcinoma the oral cancer foundation. Management of mucoepidermoid carcinoma of the palate. However, the palate is a frequent site when it occurs in the minor glands. Mucoepidermoid carcinoma mec is the epithelial salivary gland neoplasm of the oral cavity. Mucoepidermoid carcinoma mec is a malignant salivary gland tumor that arises from the pluripotent cells of the excretory duct. Sneha,2nunnasaichitra,2karenboaz,2 and nidhi manaktala2.
Mucoepidermoid carcinoma of palate mimicking vascular lesion. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac, and thyroid gland. The who in 1990 classified it as a malignant neoplasm and named it as mec. The case presented is a 41 year old woman with central mucoepidermoid carcinoma at the left posterior of the mandible. Mucicarmine staining is one stain used by pathologist for detection.
Lowgrade mucoepidermoid carcinoma of the hard palate. Maxillary mec have a worse prognosis than mandibular lesions and it should be followedup for a longer period due to the possibility of late recurrence or regional metastasis. About 5% of these tumors occur in patients younger than 18yearold with women mostly affected. Mucoepidermoid carcinoma of hard palate gill s, mohan a. Although relatively rare, minor salivary gland tumors are more likely to be malignant in pediatric patients than in adults. Complementary studies to compare carbohydrates of the normal salivary glands must be carried out because subtle alterations in tumor cells glycosylation can influence. Central mucoepidermoid carcinoma cmc is an uncommon tumor, comprising 23 % of all mucoepidermoid carcinomas reported. Mucoepidermoid carcinoma of the soft palate salivary gland. It accounts for nov 02, 2014 mucoepidermoid carcinoma mec is the epithelial salivary gland neoplasm of the oral cavity. Mucoepidermoid carcinoma palate low grade help cancer. Mucoepidermoid carcinoma of salivary glands radiology. Management of mucoepidermoid carcinoma of the palate utilizing ffdg petct year.
Occasional focal sebaceous cells, goblet type cells, oncocytic change, inflammatory reaction to extravasated mucin or keratin. Mucoepidermoid carcinoma left hard palate, intermediate. Recent development of salivary gland pathology revealed recurrent gene rearrangements in many kinds of tumors, including maml2 fusion of mec. Ive been told margins were free and i dont need any radiation or chemio. The objective of this work is to elucidate the diagnosis of lesion in the hard palate of an adolescent patient, brownskinned, male, forwarded to the oral surgery department at the state university of londrina. The origin of a salivary gland tumour is attributed to cells at various levels of differentiation which present histologically as diverse tissues and cellular patterns. Ossified mucoepidermoid carcinoma of the hard palate. Mucoepidermoid carcinoma what is, treatment, survival rate. Mucoepidermoid carcinoma of palate a rare entity ncbi. Epithelial neoplasms originating in the minor salivary glands account for approximately 15% of all salivary gland neoplasms 6, 38. It accounts for mucoepidermoid carcinoma of hard palate.
Mucoepidermoid carcinoma or mucoepidermoid tumor is the most common malignant salivary gland neoplasm. They contain three cellular elements in varying proportions. Mucoepidermoid carcinoma an overview sciencedirect topics. Pdf mucoepidermoid carcinomas mecs of minor salivary gland origin are rare in children and adolescents and have been reported rarely. Mucoepidermoid carcinoma of palate a case report and. Mucoepidermoid carcinoma is the most common primary carcinoma of major and minor salivary glands, accounting for about onethird of all salivary carcinomas. Mec was first reported by massao and berger in 1942 as a distinct. The most common types of salivary gland tumors of epithelial origin are the pleomorphic adenoma and the mucoepidermoid carcinoma. Coronal ct image shows the lesion as a faint soft tissue mass arrow on the palate.
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